I'm coming off of a Hayabusa that I was using mostly as a sport touring machine. Put 54,000 miles on that thing. Last summer I did a 10 day, 4500 mile trip from Nebraska to southern California.
I really need a bike that doesn't have a chain drive and has some kind of hard luggage. It needs to have factory cruise control, or at least be able to install an aftermarket cruise relatively easy. Most of the time I'll be using the bike as a touring machine. Usually take 2 or 3 multiday trips throughout the summer. Ride mostly with Harley or BMW guys.
I would say the Victory Cross Country is at the top of my list, but comes with a hefty price tag. The Vaquero is a better priced option in the same bagger category. I did test rides on both last summer and both felt good on the short 15 mile rides. The downsides the Vaquero seems to have compared to the Victory would be the exhaust heat (which can be dealt with and improved), the smaller side loading bags, and the overall build quality seems just a tad lower. But the lower price seems to make these differences a little easier to deal with.
My other option was to stay with an actual sport touring bike. I was looking at the Kawi Concours. No cruise control, but has aftermarket options that doesn't seem to difficult to install. Good sized luggage and still friendly ergos. Just saw yesterday that the new 2013 FJR1300 actually comes with factory cruise so now I might throw that in the mix even though it only has a 5 speed transmission.
If I go with a bagger instead of a sport touring bike I know I might miss the HP a little bit, but I've dealt with enough cops in my time, so slowing down a bit and just cruising doesn't sound to bad. Having a radio for 500-600 mile days is really tempting. I had a cruiser before my Busa that I got along well with, but just wan't at that point in my life where I was ready to sit behind a windscreen all day. I'm inching closer to 40 and my body is wanting some better ergos than the Busa could offer.